Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.
Identifieur interne : 000033 ( Main/Exploration ); précédent : 000032; suivant : 000034Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.
Auteurs : Darina Czamara [Allemagne] ; Elleke Tissink [Pays-Bas] ; Johanna Tuhkanen [Finlande] ; Jade Martins [Allemagne] ; Yvonne Awaloff [Allemagne] ; Amanda J. Drake [Royaume-Uni] ; Batbayar Khulan [Royaume-Uni] ; Aarno Palotie [Finlande] ; Sibylle M. Winter [Allemagne] ; Charles B. Nemeroff [États-Unis] ; W Edward Craighead [États-Unis] ; Boadie W. Dunlop [États-Unis] ; Helen S. Mayberg [États-Unis] ; Becky Kinkead [États-Unis] ; Sanjay J. Mathew [États-Unis] ; Dan V. Iosifescu [États-Unis] ; Thomas C. Neylan [États-Unis] ; Christine M. Heim [Allemagne] ; Jari Lahti [Finlande] ; Johan G. Eriksson [Finlande, Singapour] ; Katri R Ikkönen [Finlande] ; Kerry J. Ressler [États-Unis] ; Nadine Provençal [Canada] ; Elisabeth B. Binder [Allemagne, États-Unis]Source :
- Translational psychiatry [ 2158-3188 ] ; 2021.
Abstract
Lasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk, may be embedded via epigenetic mechanisms but findings from human studies investigating the main effects of such exposure on epigenetic measures, including DNA methylation (DNAm), are inconsistent. Studies in perinatal tissues indicate that variability of DNAm at birth is best explained by the joint effects of genotype and prenatal environment. Here, we extend these analyses to postnatal stressors. We investigated the contribution of CA, cis genotype (G), and their additive (G + CA) and interactive (G × CA) effects to DNAm variability in blood or saliva from five independent cohorts with a total sample size of 1074 ranging in age from childhood to late adulthood. Of these, 541 were exposed to CA, which was assessed retrospectively using self-reports or verified through social services and registries. For the majority of sites (over 50%) in the adult cohorts, variability in DNAm was best explained by G + CA or G × CA but almost never by CA alone. Across ages and tissues, 1672 DNAm sites showed consistency of the best model in all five cohorts, with G × CA interactions explaining most variance. The consistent G × CA sites mapped to genes enriched in brain-specific transcripts and Gene Ontology terms related to development and synaptic function. Interaction of CA with genotypes showed the strongest contribution to DNAm variability, with stable effects across cohorts in functionally relevant genes. This underscores the importance of including genotype in studies investigating the impact of environmental factors on epigenetic marks.
DOI: 10.1038/s41398-020-01147-z
PubMed: 33526782
PubMed Central: PMC7851167
Affiliations:
- Allemagne, Canada, Finlande, Pays-Bas, Royaume-Uni, Singapour, États-Unis
- Bavière, Berlin, Californie, District de Haute-Bavière, Finlande occidentale, Hollande-Septentrionale, Texas, Uusimaa, État de New York
- Amsterdam, Austin (Texas), Berlin, Helsinki, Munich, Turku
- Université d'Helsinki, Université de Turku, Université du Texas à Austin, Université nationale de Singapour
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.</title><author><name sortKey="Czamara, Darina" sort="Czamara, Darina" uniqKey="Czamara D" first="Darina" last="Czamara">Darina Czamara</name><affiliation wicri:level="3"><nlm:affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany. darina@psych.mpg.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Tissink, Elleke" sort="Tissink, Elleke" uniqKey="Tissink E" first="Elleke" last="Tissink">Elleke Tissink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Tuhkanen, Johanna" sort="Tuhkanen, Johanna" uniqKey="Tuhkanen J" first="Johanna" last="Tuhkanen">Johanna Tuhkanen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Martins, Jade" sort="Martins, Jade" uniqKey="Martins J" first="Jade" last="Martins">Jade Martins</name><affiliation wicri:level="3"><nlm:affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Awaloff, Yvonne" sort="Awaloff, Yvonne" uniqKey="Awaloff Y" first="Yvonne" last="Awaloff">Yvonne Awaloff</name><affiliation wicri:level="3"><nlm:affiliation>Sopra Steria, 80804, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sopra Steria, 80804, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Drake, Amanda J" sort="Drake, Amanda J" uniqKey="Drake A" first="Amanda J" last="Drake">Amanda J. Drake</name><affiliation wicri:level="1"><nlm:affiliation>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ</wicri:regionArea><wicri:noRegion>EH16 4TJ</wicri:noRegion></affiliation></author><author><name sortKey="Khulan, Batbayar" sort="Khulan, Batbayar" uniqKey="Khulan B" first="Batbayar" last="Khulan">Batbayar Khulan</name><affiliation wicri:level="1"><nlm:affiliation>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ</wicri:regionArea><wicri:noRegion>EH16 4TJ</wicri:noRegion></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Winter, Sibylle M" sort="Winter, Sibylle M" uniqKey="Winter S" first="Sibylle M" last="Winter">Sibylle M. Winter</name><affiliation wicri:level="3"><nlm:affiliation>Department of Child and Adolescent Psychiatry, Charité-Universitätsmedizin Berlin, Campus Virchow, 13353, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry, Charité-Universitätsmedizin Berlin, Campus Virchow, 13353, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Nemeroff, Charles B" sort="Nemeroff, Charles B" uniqKey="Nemeroff C" first="Charles B" last="Nemeroff">Charles B. Nemeroff</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Dell Medical School, University of Texas at Austin, 1601 Trinity St, Austin, TX, 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Dell Medical School, University of Texas at Austin, 1601 Trinity St, Austin, TX, 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Craighead, W Edward" sort="Craighead, W Edward" uniqKey="Craighead W" first="W Edward" last="Craighead">W Edward Craighead</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation></author><author><name sortKey="Dunlop, Boadie W" sort="Dunlop, Boadie W" uniqKey="Dunlop B" first="Boadie W" last="Dunlop">Boadie W. Dunlop</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation></author><author><name sortKey="Mayberg, Helen S" sort="Mayberg, Helen S" uniqKey="Mayberg H" first="Helen S" last="Mayberg">Helen S. Mayberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Kinkead, Becky" sort="Kinkead, Becky" uniqKey="Kinkead B" first="Becky" last="Kinkead">Becky Kinkead</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation></author><author><name sortKey="Mathew, Sanjay J" sort="Mathew, Sanjay J" uniqKey="Mathew S" first="Sanjay J" last="Mathew">Sanjay J. Mathew</name><affiliation wicri:level="2"><nlm:affiliation>Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine Mental Health Care Line, Michael E. Debakey VA Medical Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine Mental Health Care Line, Michael E. Debakey VA Medical Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Iosifescu, Dan V" sort="Iosifescu, Dan V" uniqKey="Iosifescu D" first="Dan V" last="Iosifescu">Dan V. Iosifescu</name><affiliation wicri:level="1"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>NYU School of Medicine and Nathan Kline Institute, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>NYU School of Medicine and Nathan Kline Institute, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Neylan, Thomas C" sort="Neylan, Thomas C" uniqKey="Neylan T" first="Thomas C" last="Neylan">Thomas C. Neylan</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Psychiatry and Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Psychiatry and Neurology, University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Heim, Christine M" sort="Heim, Christine M" uniqKey="Heim C" first="Christine M" last="Heim">Christine M. Heim</name><affiliation wicri:level="3"><nlm:affiliation>Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Institute of Medical Psychology, Luisenstraße 57, 10117, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Institute of Medical Psychology, Luisenstraße 57, 10117, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Turku Institute for Advanced Studies, University of Turku, 20500, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku Institute for Advanced Studies, University of Turku, 20500, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Practice and Primary Health Care, Helsinki University Hospital, University of Helsinki, 00290, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of General Practice and Primary Health Care, Helsinki University Hospital, University of Helsinki, 00290, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Folkhälsan Research Center, 00250, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhälsan Research Center, 00250, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Singapore Institute for Clinical Sciences, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Institute for Clinical Sciences, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Ressler, Kerry J" sort="Ressler, Kerry J" uniqKey="Ressler K" first="Kerry J" last="Ressler">Kerry J. Ressler</name><affiliation wicri:level="1"><nlm:affiliation>Mailman Research Center, 115 Mill St., Mailstop 339, Belmont, MA, 02478, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mailman Research Center, 115 Mill St., Mailstop 339, Belmont, MA, 02478</wicri:regionArea><wicri:noRegion>02478</wicri:noRegion></affiliation></author><author><name sortKey="Provencal, Nadine" sort="Provencal, Nadine" uniqKey="Provencal N" first="Nadine" last="Provençal">Nadine Provençal</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>BC Children's Hospital Research Institute, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>BC Children's Hospital Research Institute, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Binder, Elisabeth B" sort="Binder, Elisabeth B" uniqKey="Binder E" first="Elisabeth B" last="Binder">Elisabeth B. Binder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany. binder@psych.mpg.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA. binder@psych.mpg.de.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33526782</idno><idno type="pmid">33526782</idno><idno type="doi">10.1038/s41398-020-01147-z</idno><idno type="pmc">PMC7851167</idno><idno type="wicri:Area/Main/Corpus">000014</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000014</idno><idno type="wicri:Area/Main/Curation">000014</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000014</idno><idno type="wicri:Area/Main/Exploration">000014</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.</title><author><name sortKey="Czamara, Darina" sort="Czamara, Darina" uniqKey="Czamara D" first="Darina" last="Czamara">Darina Czamara</name><affiliation wicri:level="3"><nlm:affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany. darina@psych.mpg.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Tissink, Elleke" sort="Tissink, Elleke" uniqKey="Tissink E" first="Elleke" last="Tissink">Elleke Tissink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Tuhkanen, Johanna" sort="Tuhkanen, Johanna" uniqKey="Tuhkanen J" first="Johanna" last="Tuhkanen">Johanna Tuhkanen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Martins, Jade" sort="Martins, Jade" uniqKey="Martins J" first="Jade" last="Martins">Jade Martins</name><affiliation wicri:level="3"><nlm:affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Awaloff, Yvonne" sort="Awaloff, Yvonne" uniqKey="Awaloff Y" first="Yvonne" last="Awaloff">Yvonne Awaloff</name><affiliation wicri:level="3"><nlm:affiliation>Sopra Steria, 80804, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sopra Steria, 80804, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Drake, Amanda J" sort="Drake, Amanda J" uniqKey="Drake A" first="Amanda J" last="Drake">Amanda J. Drake</name><affiliation wicri:level="1"><nlm:affiliation>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ</wicri:regionArea><wicri:noRegion>EH16 4TJ</wicri:noRegion></affiliation></author><author><name sortKey="Khulan, Batbayar" sort="Khulan, Batbayar" uniqKey="Khulan B" first="Batbayar" last="Khulan">Batbayar Khulan</name><affiliation wicri:level="1"><nlm:affiliation>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ</wicri:regionArea><wicri:noRegion>EH16 4TJ</wicri:noRegion></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Winter, Sibylle M" sort="Winter, Sibylle M" uniqKey="Winter S" first="Sibylle M" last="Winter">Sibylle M. Winter</name><affiliation wicri:level="3"><nlm:affiliation>Department of Child and Adolescent Psychiatry, Charité-Universitätsmedizin Berlin, Campus Virchow, 13353, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry, Charité-Universitätsmedizin Berlin, Campus Virchow, 13353, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Nemeroff, Charles B" sort="Nemeroff, Charles B" uniqKey="Nemeroff C" first="Charles B" last="Nemeroff">Charles B. Nemeroff</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Dell Medical School, University of Texas at Austin, 1601 Trinity St, Austin, TX, 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Dell Medical School, University of Texas at Austin, 1601 Trinity St, Austin, TX, 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Craighead, W Edward" sort="Craighead, W Edward" uniqKey="Craighead W" first="W Edward" last="Craighead">W Edward Craighead</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation></author><author><name sortKey="Dunlop, Boadie W" sort="Dunlop, Boadie W" uniqKey="Dunlop B" first="Boadie W" last="Dunlop">Boadie W. Dunlop</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation></author><author><name sortKey="Mayberg, Helen S" sort="Mayberg, Helen S" uniqKey="Mayberg H" first="Helen S" last="Mayberg">Helen S. Mayberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Kinkead, Becky" sort="Kinkead, Becky" uniqKey="Kinkead B" first="Becky" last="Kinkead">Becky Kinkead</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation></author><author><name sortKey="Mathew, Sanjay J" sort="Mathew, Sanjay J" uniqKey="Mathew S" first="Sanjay J" last="Mathew">Sanjay J. Mathew</name><affiliation wicri:level="2"><nlm:affiliation>Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine Mental Health Care Line, Michael E. Debakey VA Medical Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine Mental Health Care Line, Michael E. Debakey VA Medical Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Iosifescu, Dan V" sort="Iosifescu, Dan V" uniqKey="Iosifescu D" first="Dan V" last="Iosifescu">Dan V. Iosifescu</name><affiliation wicri:level="1"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>NYU School of Medicine and Nathan Kline Institute, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>NYU School of Medicine and Nathan Kline Institute, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Neylan, Thomas C" sort="Neylan, Thomas C" uniqKey="Neylan T" first="Thomas C" last="Neylan">Thomas C. Neylan</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Psychiatry and Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Psychiatry and Neurology, University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Heim, Christine M" sort="Heim, Christine M" uniqKey="Heim C" first="Christine M" last="Heim">Christine M. Heim</name><affiliation wicri:level="3"><nlm:affiliation>Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Institute of Medical Psychology, Luisenstraße 57, 10117, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Institute of Medical Psychology, Luisenstraße 57, 10117, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Turku Institute for Advanced Studies, University of Turku, 20500, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku Institute for Advanced Studies, University of Turku, 20500, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Practice and Primary Health Care, Helsinki University Hospital, University of Helsinki, 00290, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of General Practice and Primary Health Care, Helsinki University Hospital, University of Helsinki, 00290, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Folkhälsan Research Center, 00250, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhälsan Research Center, 00250, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Singapore Institute for Clinical Sciences, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Institute for Clinical Sciences, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Ressler, Kerry J" sort="Ressler, Kerry J" uniqKey="Ressler K" first="Kerry J" last="Ressler">Kerry J. Ressler</name><affiliation wicri:level="1"><nlm:affiliation>Mailman Research Center, 115 Mill St., Mailstop 339, Belmont, MA, 02478, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mailman Research Center, 115 Mill St., Mailstop 339, Belmont, MA, 02478</wicri:regionArea><wicri:noRegion>02478</wicri:noRegion></affiliation></author><author><name sortKey="Provencal, Nadine" sort="Provencal, Nadine" uniqKey="Provencal N" first="Nadine" last="Provençal">Nadine Provençal</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>BC Children's Hospital Research Institute, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>BC Children's Hospital Research Institute, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Binder, Elisabeth B" sort="Binder, Elisabeth B" uniqKey="Binder E" first="Elisabeth B" last="Binder">Elisabeth B. Binder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany. binder@psych.mpg.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA. binder@psych.mpg.de.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329</wicri:regionArea><wicri:noRegion>30329</wicri:noRegion></affiliation></author></analytic><series><title level="j">Translational psychiatry</title><idno type="eISSN">2158-3188</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk, may be embedded via epigenetic mechanisms but findings from human studies investigating the main effects of such exposure on epigenetic measures, including DNA methylation (DNAm), are inconsistent. Studies in perinatal tissues indicate that variability of DNAm at birth is best explained by the joint effects of genotype and prenatal environment. Here, we extend these analyses to postnatal stressors. We investigated the contribution of CA, cis genotype (G), and their additive (G + CA) and interactive (G × CA) effects to DNAm variability in blood or saliva from five independent cohorts with a total sample size of 1074 ranging in age from childhood to late adulthood. Of these, 541 were exposed to CA, which was assessed retrospectively using self-reports or verified through social services and registries. For the majority of sites (over 50%) in the adult cohorts, variability in DNAm was best explained by G + CA or G × CA but almost never by CA alone. Across ages and tissues, 1672 DNAm sites showed consistency of the best model in all five cohorts, with G × CA interactions explaining most variance. The consistent G × CA sites mapped to genes enriched in brain-specific transcripts and Gene Ontology terms related to development and synaptic function. Interaction of CA with genotypes showed the strongest contribution to DNAm variability, with stable effects across cohorts in functionally relevant genes. This underscores the importance of including genotype in studies investigating the impact of environmental factors on epigenetic marks.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">33526782</PMID><DateRevised><Year>2021</Year><Month>02</Month><Day>11</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2158-3188</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>1</Issue><PubDate><Year>2021</Year><Month>Feb</Month><Day>01</Day></PubDate></JournalIssue><Title>Translational psychiatry</Title><ISOAbbreviation>Transl Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.</ArticleTitle><Pagination><MedlinePgn>88</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41398-020-01147-z</ELocationID><Abstract><AbstractText>Lasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk, may be embedded via epigenetic mechanisms but findings from human studies investigating the main effects of such exposure on epigenetic measures, including DNA methylation (DNAm), are inconsistent. Studies in perinatal tissues indicate that variability of DNAm at birth is best explained by the joint effects of genotype and prenatal environment. Here, we extend these analyses to postnatal stressors. We investigated the contribution of CA, cis genotype (G), and their additive (G + CA) and interactive (G × CA) effects to DNAm variability in blood or saliva from five independent cohorts with a total sample size of 1074 ranging in age from childhood to late adulthood. Of these, 541 were exposed to CA, which was assessed retrospectively using self-reports or verified through social services and registries. For the majority of sites (over 50%) in the adult cohorts, variability in DNAm was best explained by G + CA or G × CA but almost never by CA alone. Across ages and tissues, 1672 DNAm sites showed consistency of the best model in all five cohorts, with G × CA interactions explaining most variance. The consistent G × CA sites mapped to genes enriched in brain-specific transcripts and Gene Ontology terms related to development and synaptic function. Interaction of CA with genotypes showed the strongest contribution to DNAm variability, with stable effects across cohorts in functionally relevant genes. This underscores the importance of including genotype in studies investigating the impact of environmental factors on epigenetic marks.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Czamara</LastName><ForeName>Darina</ForeName><Initials>D</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7381-904X</Identifier><AffiliationInfo><Affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany. darina@psych.mpg.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tissink</LastName><ForeName>Elleke</ForeName><Initials>E</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-4225-9347</Identifier><AffiliationInfo><Affiliation>Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tuhkanen</LastName><ForeName>Johanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martins</LastName><ForeName>Jade</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6528-8947</Identifier><AffiliationInfo><Affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Awaloff</LastName><ForeName>Yvonne</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Sopra Steria, 80804, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drake</LastName><ForeName>Amanda J</ForeName><Initials>AJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-8633-333X</Identifier><AffiliationInfo><Affiliation>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khulan</LastName><ForeName>Batbayar</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palotie</LastName><ForeName>Aarno</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Winter</LastName><ForeName>Sibylle M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry, Charité-Universitätsmedizin Berlin, Campus Virchow, 13353, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nemeroff</LastName><ForeName>Charles B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dell Medical School, University of Texas at Austin, 1601 Trinity St, Austin, TX, 78712, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Craighead</LastName><ForeName>W Edward</ForeName><Initials>WE</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9957-0027</Identifier><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dunlop</LastName><ForeName>Boadie W</ForeName><Initials>BW</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4653-0483</Identifier><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayberg</LastName><ForeName>Helen S</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kinkead</LastName><ForeName>Becky</ForeName><Initials>B</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-0169-6989</Identifier><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathew</LastName><ForeName>Sanjay J</ForeName><Initials>SJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2715-6641</Identifier><AffiliationInfo><Affiliation>Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine Mental Health Care Line, Michael E. Debakey VA Medical Center, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iosifescu</LastName><ForeName>Dan V</ForeName><Initials>DV</Initials><AffiliationInfo><Affiliation>Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy PI, New York, NY, 10029, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NYU School of Medicine and Nathan Kline Institute, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neylan</LastName><ForeName>Thomas C</ForeName><Initials>TC</Initials><AffiliationInfo><Affiliation>Departments of Psychiatry and Neurology, University of California, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heim</LastName><ForeName>Christine M</ForeName><Initials>CM</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6580-6326</Identifier><AffiliationInfo><Affiliation>Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Institute of Medical Psychology, Luisenstraße 57, 10117, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lahti</LastName><ForeName>Jari</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4310-5297</Identifier><AffiliationInfo><Affiliation>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Turku Institute for Advanced Studies, University of Turku, 20500, Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>Johan G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of General Practice and Primary Health Care, Helsinki University Hospital, University of Helsinki, 00290, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Folkhälsan Research Center, 00250, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Singapore Institute for Clinical Sciences, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Räikkönen</LastName><ForeName>Katri</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ressler</LastName><ForeName>Kerry J</ForeName><Initials>KJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5158-1103</Identifier><AffiliationInfo><Affiliation>Mailman Research Center, 115 Mill St., Mailstop 339, Belmont, MA, 02478, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Provençal</LastName><ForeName>Nadine</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>BC Children's Hospital Research Institute, Vancouver, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Binder</LastName><ForeName>Elisabeth B</ForeName><Initials>EB</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7088-6618</Identifier><AffiliationInfo><Affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany. binder@psych.mpg.de.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Dr, Atlanta, GA, 30329, USA. binder@psych.mpg.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U19 MH069056</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH071537</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>M01 RR000039</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH080880</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 RR025008</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 MH077083</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><Acronym>WT_</Acronym><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>02</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Transl Psychiatry</MedlineTA><NlmUniqueID>101562664</NlmUniqueID><ISSNLinking>2158-3188</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>11</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>12</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>12</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>4</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33526782</ArticleId><ArticleId IdType="doi">10.1038/s41398-020-01147-z</ArticleId><ArticleId IdType="pii">10.1038/s41398-020-01147-z</ArticleId><ArticleId IdType="pmc">PMC7851167</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Trials. 2012 Jul 09;13:106</Citation><ArticleIdList><ArticleId IdType="pubmed">22776534</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Res. 2014 Jul;24(7):1064-74</Citation><ArticleIdList><ArticleId IdType="pubmed">24709820</ArticleId></ArticleIdList></Reference><Reference><Citation>G3 (Bethesda). 2016 Apr 07;6(4):973-86</Citation><ArticleIdList><ArticleId IdType="pubmed">26888867</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2019 Jun 11;10(1):2548</Citation><ArticleIdList><ArticleId IdType="pubmed">31186427</ArticleId></ArticleIdList></Reference><Reference><Citation>J Trauma Stress. 2008 Apr;21(2):218-22</Citation><ArticleIdList><ArticleId IdType="pubmed">18404649</ArticleId></ArticleIdList></Reference><Reference><Citation>Child Dev. 2013 Jan-Feb;84(1):49-57</Citation><ArticleIdList><ArticleId IdType="pubmed">22880724</ArticleId></ArticleIdList></Reference><Reference><Citation>Transl Psychiatry. 2014 Sep 23;4:e448</Citation><ArticleIdList><ArticleId IdType="pubmed">25247593</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Methods. 2015 Oct;12(10):931-4</Citation><ArticleIdList><ArticleId IdType="pubmed">26301843</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2014 Feb 21;15:145</Citation><ArticleIdList><ArticleId IdType="pubmed">24555763</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2012 Mar 15;28(6):882-3</Citation><ArticleIdList><ArticleId IdType="pubmed">22257669</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychol Bull. 2004 Jul;130(4):601-30</Citation><ArticleIdList><ArticleId IdType="pubmed">15250815</ArticleId></ArticleIdList></Reference><Reference><Citation>Biol Psychiatry. 2017 Dec 15;82(12):866-874</Citation><ArticleIdList><ArticleId IdType="pubmed">28793974</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013 May 17;8(5):e63812</Citation><ArticleIdList><ArticleId IdType="pubmed">23691101</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Bioinformatics. 2012 May 08;13:86</Citation><ArticleIdList><ArticleId IdType="pubmed">22568884</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2013 Aug 22;500(7463):477-81</Citation><ArticleIdList><ArticleId IdType="pubmed">23925113</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2014 May 15;30(10):1363-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24478339</ArticleId></ArticleIdList></Reference><Reference><Citation>Biostatistics. 2007 Jan;8(1):118-27</Citation><ArticleIdList><ArticleId IdType="pubmed">16632515</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2010 Oct 28;467(7319):1061-73</Citation><ArticleIdList><ArticleId IdType="pubmed">20981092</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Epigenetics. 2014 Feb 03;6(1):4</Citation><ArticleIdList><ArticleId IdType="pubmed">24485148</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Psychiatry. 2010 Nov;197(5):378-85</Citation><ArticleIdList><ArticleId IdType="pubmed">21037215</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2018 May 23;19(1):61</Citation><ArticleIdList><ArticleId IdType="pubmed">29792225</ArticleId></ArticleIdList></Reference><Reference><Citation>J Affect Disord. 2011 Nov;134(1-3):160-7</Citation><ArticleIdList><ArticleId IdType="pubmed">21665286</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2017 Jan;49(1):131-138</Citation><ArticleIdList><ArticleId IdType="pubmed">27918535</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Biotechnol. 2010 Oct;28(10):1057-68</Citation><ArticleIdList><ArticleId IdType="pubmed">20944598</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetologia. 2006 Dec;49(12):2853-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17096117</ArticleId></ArticleIdList></Reference><Reference><Citation>Elife. 2013 Jun 04;2:e00523</Citation><ArticleIdList><ArticleId IdType="pubmed">23755361</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Public Health. 2001 May;91(5):753-60</Citation><ArticleIdList><ArticleId IdType="pubmed">11344883</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2009 Jun;5(6):e1000529</Citation><ArticleIdList><ArticleId IdType="pubmed">19543373</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Epidemiol. 2018 Aug 1;47(4):1120-1130</Citation><ArticleIdList><ArticleId IdType="pubmed">29860346</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychosom Med. 2008 Apr;70(3):306-13</Citation><ArticleIdList><ArticleId IdType="pubmed">18378874</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2010 May 13;6(5):e1000952</Citation><ArticleIdList><ArticleId IdType="pubmed">20485568</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Psychiatry. 2018 Jun 1;175(6):517-529</Citation><ArticleIdList><ArticleId IdType="pubmed">29325449</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2013 Jun;45(6):580-5</Citation><ArticleIdList><ArticleId IdType="pubmed">23715323</ArticleId></ArticleIdList></Reference><Reference><Citation>Gen Hosp Psychiatry. 2009 Nov-Dec;31(6):505-14</Citation><ArticleIdList><ArticleId IdType="pubmed">19892208</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2005 Oct 27;353(17):1802-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16251536</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2017 Nov 28;8(1):1826</Citation><ArticleIdList><ArticleId IdType="pubmed">29184056</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Pediatr. 2017 Dec 1;171(12):1168-1175</Citation><ArticleIdList><ArticleId IdType="pubmed">29084329</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2015 Jul 15;31(14):2382-3</Citation><ArticleIdList><ArticleId IdType="pubmed">25765347</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Med Genet B Neuropsychiatr Genet. 2015 Jan;168B(1):36-44</Citation><ArticleIdList><ArticleId IdType="pubmed">25355443</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Child Adolesc Psychiatry. 2020 Oct;29(10):1329-1338</Citation><ArticleIdList><ArticleId IdType="pubmed">30968208</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hum Genet. 2007 Sep;81(3):559-75</Citation><ArticleIdList><ArticleId IdType="pubmed">17701901</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Psychiatry. 1994 Aug;151(8):1132-6</Citation><ArticleIdList><ArticleId IdType="pubmed">8037246</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2014 Dec 03;15(12):503</Citation><ArticleIdList><ArticleId IdType="pubmed">25599564</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychoneuroendocrinology. 2010 Jun;35(5):758-67</Citation><ArticleIdList><ArticleId IdType="pubmed">19963324</ArticleId></ArticleIdList></Reference><Reference><Citation>Epigenetics. 2013 Feb;8(2):203-9</Citation><ArticleIdList><ArticleId IdType="pubmed">23314698</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2015 Dec 17;16:266</Citation><ArticleIdList><ArticleId IdType="pubmed">26673150</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2016 Mar 31;17:61</Citation><ArticleIdList><ArticleId IdType="pubmed">27036880</ArticleId></ArticleIdList></Reference><Reference><Citation>Child Maltreat. 2019 Nov;24(4):458-465</Citation><ArticleIdList><ArticleId IdType="pubmed">31495193</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Epidemiol. 2012 Feb;41(1):200-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22422453</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Genet. 2019 Aug;20(8):437-455</Citation><ArticleIdList><ArticleId IdType="pubmed">31086298</ArticleId></ArticleIdList></Reference><Reference><Citation>Neurosci Biobehav Rev. 2020 May;112:392-409</Citation><ArticleIdList><ArticleId IdType="pubmed">32081689</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Finlande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Singapour</li><li>États-Unis</li></country><region><li>Bavière</li><li>Berlin</li><li>Californie</li><li>District de Haute-Bavière</li><li>Finlande occidentale</li><li>Hollande-Septentrionale</li><li>Texas</li><li>Uusimaa</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Austin (Texas)</li><li>Berlin</li><li>Helsinki</li><li>Munich</li><li>Turku</li></settlement><orgName><li>Université d'Helsinki</li><li>Université de Turku</li><li>Université du Texas à Austin</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Czamara, Darina" sort="Czamara, Darina" uniqKey="Czamara D" first="Darina" last="Czamara">Darina Czamara</name></region><name sortKey="Awaloff, Yvonne" sort="Awaloff, Yvonne" uniqKey="Awaloff Y" first="Yvonne" last="Awaloff">Yvonne Awaloff</name><name sortKey="Binder, Elisabeth B" sort="Binder, Elisabeth B" uniqKey="Binder E" first="Elisabeth B" last="Binder">Elisabeth B. Binder</name><name sortKey="Heim, Christine M" sort="Heim, Christine M" uniqKey="Heim C" first="Christine M" last="Heim">Christine M. Heim</name><name sortKey="Martins, Jade" sort="Martins, Jade" uniqKey="Martins J" first="Jade" last="Martins">Jade Martins</name><name sortKey="Winter, Sibylle M" sort="Winter, Sibylle M" uniqKey="Winter S" first="Sibylle M" last="Winter">Sibylle M. Winter</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Tissink, Elleke" sort="Tissink, Elleke" uniqKey="Tissink E" first="Elleke" last="Tissink">Elleke Tissink</name></region></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Tuhkanen, Johanna" sort="Tuhkanen, Johanna" uniqKey="Tuhkanen J" first="Johanna" last="Tuhkanen">Johanna Tuhkanen</name></region><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Drake, Amanda J" sort="Drake, Amanda J" uniqKey="Drake A" first="Amanda J" last="Drake">Amanda J. Drake</name></noRegion><name sortKey="Khulan, Batbayar" sort="Khulan, Batbayar" uniqKey="Khulan B" first="Batbayar" last="Khulan">Batbayar Khulan</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Nemeroff, Charles B" sort="Nemeroff, Charles B" uniqKey="Nemeroff C" first="Charles B" last="Nemeroff">Charles B. Nemeroff</name></region><name sortKey="Binder, Elisabeth B" sort="Binder, Elisabeth B" uniqKey="Binder E" first="Elisabeth B" last="Binder">Elisabeth B. Binder</name><name sortKey="Craighead, W Edward" sort="Craighead, W Edward" uniqKey="Craighead W" first="W Edward" last="Craighead">W Edward Craighead</name><name sortKey="Dunlop, Boadie W" sort="Dunlop, Boadie W" uniqKey="Dunlop B" first="Boadie W" last="Dunlop">Boadie W. Dunlop</name><name sortKey="Iosifescu, Dan V" sort="Iosifescu, Dan V" uniqKey="Iosifescu D" first="Dan V" last="Iosifescu">Dan V. Iosifescu</name><name sortKey="Iosifescu, Dan V" sort="Iosifescu, Dan V" uniqKey="Iosifescu D" first="Dan V" last="Iosifescu">Dan V. Iosifescu</name><name sortKey="Kinkead, Becky" sort="Kinkead, Becky" uniqKey="Kinkead B" first="Becky" last="Kinkead">Becky Kinkead</name><name sortKey="Mathew, Sanjay J" sort="Mathew, Sanjay J" uniqKey="Mathew S" first="Sanjay J" last="Mathew">Sanjay J. Mathew</name><name sortKey="Mayberg, Helen S" sort="Mayberg, Helen S" uniqKey="Mayberg H" first="Helen S" last="Mayberg">Helen S. Mayberg</name><name sortKey="Mayberg, Helen S" sort="Mayberg, Helen S" uniqKey="Mayberg H" first="Helen S" last="Mayberg">Helen S. Mayberg</name><name sortKey="Neylan, Thomas C" sort="Neylan, Thomas C" uniqKey="Neylan T" first="Thomas C" last="Neylan">Thomas C. Neylan</name><name sortKey="Ressler, Kerry J" sort="Ressler, Kerry J" uniqKey="Ressler K" first="Kerry J" last="Ressler">Kerry J. Ressler</name></country><country name="Singapour"><noRegion><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name></noRegion><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name></country><country name="Canada"><noRegion><name sortKey="Provencal, Nadine" sort="Provencal, Nadine" uniqKey="Provencal N" first="Nadine" last="Provençal">Nadine Provençal</name></noRegion><name sortKey="Provencal, Nadine" sort="Provencal, Nadine" uniqKey="Provencal N" first="Nadine" last="Provençal">Nadine Provençal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/AutomedicationFrancoV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000033 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000033 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= AutomedicationFrancoV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:33526782
|texte= Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:33526782" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AutomedicationFrancoV1
| This area was generated with Dilib version V0.6.38. |  |